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Ultrasound localization microscopy (ULM) has become a potent technique for microvascular imaging using ultrasound waves. However, one major challenge is the high frame rate and lengthy acquisition time needed to produce super-resolved (SR) images. To overcome this, our goal is to relax the frame rate and shorten this acquisition time while preserving SR image quality, thereby enhancing ULM’s […]

Angiogenesis—the formation of new blood vessels from pre-existing ones—is one of the hallmarks of cancer, regardless of subtype. However, the development of a specific tumor type is a highly heterogeneous process that influences the morphology of the tumor vasculature, which has a direct impact on the malignancy and invasiveness of the lesions. Therefore, the analysis of tumor vascularity […]

The ultrasound backscatter coefficient (BSC) is a frequency-dependent quantity intrinsic to biological tissues that can be recovered from backscattered radio frequency (RF) signals, granted acquisitions on a reference phantom (RP) are available under the same system’s settings. A phantom-free (PF) BSC estimation method is proposed based on Gaussian-shaped approximation of the point spread […]

Wearable ultrasound has been widely developed for long-term, continuous imaging without the need for bulky system manipulation and repeated manual locating. To potentially lead to more accurate and reliable imaging monitoring, this work presents the design, fabrication, and evaluation of a novel high-frequency wearable ultrasound array belt (WUAB) for small animal echocardiography. The […]

Ultrasound microvascular imaging (UMI), including ultrafast power Doppler imaging (uPDI) and ultrasound localization microscopy (ULM), obtains blood flow information through plane wave (PW) transmissions at high frame rates. However, low signal-to-noise ratio (SNR) of PWs causes low image quality. Adaptive beamformers have been proposed to suppress noise energy to achieve higher image quality […]

Super-resolution ultrasound (SRUS) visualizes microvasculature beyond the ultrasound (US) diffraction limit (wavelength( $\lambda $ )/2) by localizing and tracking spatially isolated microbubble (MB) contrast agents. SRUS phantoms typically consist of simple tube structures, where diameter channels below ${100}~{\mu }$ m are not available. Furthermore, these phantoms are generally fragile and […]

Super-resolution ultrasound (SRUS) has evolved significantly with the advent of ultrasound localization microscopy (ULM). This technique enables subwavelength resolution imaging using microbubble contrast agents. Initially confined to 2-D imaging, ULM has progressed toward volumetric approaches, allowing for comprehensive 3-D visualization of microvascular networks. This review explores the […]

Tomographic reconstruction is used extensively in medicine, nondestructive testing (NDT), and geology. In an ideal situation, where measurements are taken at all angles around an object, known as full-view configuration, a full reconstruction of the object can be produced. One of the major issues faced in tomographic imaging is when measurements cannot be taken freely around the object under […]

For ultrasound localization microscopy, the localization of microbubbles (MBs) is an essential part to obtain super-resolved maps of the vasculature. This article analyzes the impact of image discretization and patch size on the precision of different MB localization methods to reconcile different observations from previous studies, provide an estimate of feasible localization precision, and […]